Immunology · metabolism · B-cell lymphoma
Mlynarczyk Lab
Yale School of Medicine / Yale Cancer CenterWelcome to our lab
Mlynarczyk Lab
The Mlynarczyk laboratory studies the immunology and metabolism of germinal-centre-derived B-cell malignancies. It combines mechanistic models with patient-relevant systems to understand malignant competition, dissemination and treatment failure.
Principal investigator
Coraline Mlynarczyk, PhD
Assistant Professor of Medicine (Hematology)
The Mlynarczyk laboratory studies the immunology and metabolism of germinal-centre-derived B-cell malignancies. It combines mechanistic models with patient-relevant systems to understand malignant competition, dissemination and treatment failure.
View official profile →Research programmes
Four connected research programmes
01
Cell competition in germinal centres
How do B cells acquire competitive fitness that can seed malignant transformation?
02
Metabolic and biosynthetic fitness
How do highly competitive B cells sustain exceptional growth and biosynthetic demand?
03
Cell-state plasticity and lymphoma evolution
How do chromatin and signalling changes redirect B-cell fate during lymphoma initiation?
04
Dissemination, therapy resistance and vulnerabilities
Why do aggressive B-cell lymphomas escape their niches and resist treatment?
Selected publications
Recent and defining work
2026↗2025↗2024↗2023↗2020↗
Pathogenesis of diffuse large B cell lymphoma proteogenotypes
Cancer Cell
T follicular helper cells transiently unlock a plasticity state in germinal centre B cells
Nature Cell Biology
ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors
Cancer Cell
BTG1 mutation yields supercompetitive B cells primed for malignant transformation
Science
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells
Journal of Experimental Medicine
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